Study the role of oxidative stress in helicobacter pylori induced gastro-intestinal diseases

Abstract

Background: Helicobacter  pylori (H. pylori)  is a multi-flagellated, spiral-shaped, Gram-negative, microaerophilic, slow-growing bacteria and extremely mobile which colonizes the stomach mucosa of a human where it causes a long-lasting infection which consistent with either acute or chronic stomach inflammation. Current study was aimed to evaluate total antioxidant capacity (TAC) and selenium (Se) levels in the serum of H. pylori infected individuals and to elucidate the relationship between the two biomarkers. Methods: Two study groups were enrolled in a current case control study; first group was included fifty five subjects with H. pylori infection which considered as H. pylori-associated patients (HPP), and the second group included thirty five apparently healthy subjects as healthy control (HC). Subjects were selected during the period between November 2021 and June 2022 after stringent application of the eligibility criteria. The HPP group subjects were underwent endoscopy and stool antigen test (SAT) and then both study groups subjects were evaluated for their serum anti-H. pylori antibodies (Abs), TAC and Se. Results: The findings revealed a significantly lower serum TAC and Se in HPP group in comparison with HC group. Serum immunoglobulin gamma (IgG) anti-H.