Convenient one-pot synthesis of 2-carbamoylmethylthio-3-cyano-4,6-diaryl-5-ethoxycarbonyl-1,4-dihydropyridines

Abstract

2-Carbamoylmethylthio-3-cyano-4,6-diaryl-5-etfioxycarbonyl-1,4- dihydropyridines 1 were obtained by an one-pot condensation of ethyl 4-nitrobenzoylacetate, an aromatic aldehyde and cyanothioacetamide in the presence of piperidine with subsequent alkylation and dehydroxylation. Thorpe's cyclization of 1 yielded thieno[2,3-b]pyridines 3.