Vitamin D Adequacy and Improvements of Comorbidities in Persons with Intellectual Developmental Disabilities

Abstract

The prevalence of vitamin D deficiency is alarmingly high among people with developmental disabilities. In addition to enhancing mineral metabolism, vitamin D affects neuro-modulation, muscle coordination, immunity, infections and autoimmune disorders. Peer-reviewed papers from PubMed, Medline, and other research databases were searched using key words to collate relevant evidence in preparation of this evidence-based review. Per the guidelines from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), general interpretations of results are included taking into consideration the risk-benefits, broader evidence, and implications for practicing clinicians. Many clinicians consider the minimum level of serum 25-hydroxy vitamin D [25(OH)D] required for optimal health in the normal population to be 30 ng/mL (75 nmol/L), whereas a lesser number consider the level to be 20 ng/mL. However, evolving data suggest that for vulnerable populations, such as those with autoimmune disease, cancer, cardiovascular diseases, metabolic syndrome, and persons with developmental and intellectual disabilities, 40 ng/mL (100 nmol/L) might be considered the minimum level. To reach this level, most people requires adequate sun exposure and/or a daily oral supplementation of between 1,000 and 5,000 International Units of vitamin D. This review explores vitamin D requirements for the musculoskeletal and non-skeletal systems and its adequacy in relationship to common disorders affecting persons with intellectual disabilities.