Primary anaplastic large cell lymphoma of the pancreas

Abstract

Introduction: Primary pancreatic anaplastic large cell lymphoma is a very rare entity and only 13 cases have been described in the literature. Objectives: To present a rare clinical case of anaplastic large cell lymphoma negative for anaplastic lymphoma kinase and with extranodal presentation in the gastrointestinal tract. Clinical case: An 80-year-old male patient presented with abdominal pain, regurgitation, jaundice, and weight loss. Abdominal CT showed a mass in the head of the pancreas extending to segment V of the liver, accompanied by mesenteric and retroperitoneal adenopathy. Biopsy of the lesion was consistent with anaplastic lymphoma kinase-negative anaplastic large cell lymphoma. Mini-CHOP was indicated for 1 cycle. The patient subsequently developed neutropenic sepsis and died 3 months after diagnosis. Conclusions: Anaplastic lymphoma kinase-negative anaplastic large cell lymphoma is a rare entity whose extranodal localization, particularly in the gastrointestinal tract, is uncommon.