A highly efficient, eco-friendly, room temperature synthesis of Bis(indol-3-yl)methanes using the mesoporous titanosilicate Ti-TUD-1: Electrophilic substitution reactions of indoles - Part XXIII

Abstract

Bis(indol-3-yl)methanes have been synthesized at room temperature in high yields by the reaction of indole or 2-methylindole with aromatic aldehydes using the titanosilicate catalyst Ti-TUD-1 for the first time. The catalyst was recycled and reused five times with reproducible yields. This procedure has the advantage of high yields at room temperature, mildness of reaction conditions, operational simplicity and reusable nature of the catalyst which makes this protocol practically useful for the synthesis of bis(indol-3-yl)methanes.