EFFECTIVITY OF BITTER LEAF EXTRACT (Vernonia amygdalina) TOPICALLY TO RE-EPITHELIALIZATION INCISION WOUND HEALING IN RATS (Rattus novergicus)

Abstract

This study aims to determine the effect and the relation between the concetration of bitter leaf (Vernonia amygdalina) extract topically and the effectiveness of wound healing and re-epithelialization incision wound healing in rats. 20 male rats are grouped randomly divided into 5 groups, namely P0 (vaseline + adeps lanae), P1 (povidone iodine), P2 (bitter leaf extract ointment 16.8%), P3 (bitter leaf extract ointment 28 %), and P4 (bitter leaf extract ointment 39.20%). This research was carried out for 14 days by measuring the re-epithelialization scores on histopathologic preparations of treated wound skins. The results showed no significant difference between the control treatment (p> 0.05). Treatment with bitter leaf extract (Vernonia amygdalina) showed no different re-epitheliazation than control treatment.