FORMULATION AND EVALUATION OF OINTMENT CONTAINING CRISABOROLE

Abstract

Crisaborole has broad-spectrum anti-inflammatory activity by mainly targeting phosphodiesterase 4 (PDE4) enzyme that is a key regulator of inflammatory cytokine production. As this enzyme is expressed in keratinocytes and immune cells, crisaborole mediates an anti-inflammatory effect on almost all inflammatory cells. Topical application of this drug is useful as it potentiates the localization of this drug in the skin and this anti-inflammatory activity is in the low micromolar range. The objective of present research work is to enhance the aqueous solubility of poorly water soluble drug Crisaborole using Co-solvency technique. The prepared formulation was evaluated for physical characteristics, drug content and drug release. Keywords: Crisaborole, Ointment, Co-solvency