Studies Of Analgesic and Anti-Inflammatory Effects of Aqueous Extract Of Ganoderma Lucidum in Mice and Wister Rats

Abstract

The aqueous extract of Ganoderma lucidum was investigated for analgesic and anti-inflammatory effects in rodents. Investigations for analgesic effect was carried out employing the acetic acid- induced writhing in mice and the anti-inflammatory effect the hind paw edema method was employed in Wistar rats Results showed the aqueous extract to have a significant (p<0.05) analgesic activity at the doses of 50, 100 and 150mg/kg body weight intraperitoneally in mice. Also, the extract showed a significant (p<0.05) anti- inflammatory activity at doses of 50, 100 and 150mg/kg body weight. Preliminary phytochemical screening of the aqueous extract revealed the presences of Glycosides, Saponins, Flavonoids, Alkaloids, Steroids and Reducing sugars. The extract had an LD50 of 3.5g/kg body weight in Wistar rats. The results of this study confirms that the aqueous extract of Ganoderma lucidum have analgesic and anti-inflammatory activities in mice and rats.