Assessment of wound healing potential of Momordica charantia, Pongamia glabra and their combination with Piper nigrum on anemic albino rats using excision wound model

Abstract

The objective of present work was to assess the wound healing potential of Momordica charantia, Pongamia glabra and their combination with Piper nigrum using as ointment formulation on anemic albino rats using excision wound model. These all have exhibit antidiabetic, anti-inflammatory, anti-microbial, antileukemic, antimycobacterial, antioxidant, antitumor, antiulcer, antiviral, anticancer, antimalarial, cytotoxic, antiprotozoal and wound healing properties. Solvent extraction method has been utilized for the separation of the constituents of interest. Herbal ointment formulation has been prepared by mixing the extract of Momordica charantia, Pongamia glabra and their combination with Piper nigrum. Excision wound model on anemic rats has been used for the assessment of wound healing potential. The studies on excision wound healing model reveals that all twelve groups showed decreased wound area on the time and there was no mortality observed in the course of study. These studies have indicated that ointment formulation of Momordica charantia, Pongamia glabra and their combination with Piper nigrum has been utilized for wound healing and it is safer for topical application. No toxicity and mortality has been observed during the exptl. tenure.