Azepanodipterocarpol is potential candidate for inhibits influenza H1N1 type among other lupane, oleanane, and dammarane A-ring amino-triterpenoids

Irina Smirnova; Anastasiya Petrova; Alexander Lobov; El’za Minnibaeva; Thao Tran Thi Phoung; Loc Tran Van; Myint Myint Khine; Iana Esaulkova; Alexander Slita; Vladimir Zarubaev; Oxana Kazakova

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Azepanodipterocarpol is potential candidate for inhibits influenza H1N1 type among other lupane, oleanane, and dammarane A-ring amino-triterpenoids

Journal of Antibiotics (2022) 75(5) 258-267

DOI: 10.1038/s41429-022-00514-w

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Abstract

A series of lupane-, oleanane- and dammarane-based triterpenoids with 3β-amino, A-ring azepano- and 3,4-seco-fragments has been synthesized and evaluated for antiviral activity against influenza A(H1N1) virus. It was found that azepanodipterocarpol 8 and 3β-amino-28-oxoallobetulin 11 showed antiviral activity with IC50 1.1 and 2.6 μg ml−1, and selectivity index of 19 and 10, respectively.

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Smirnova, I., Petrova, A., Lobov, A., Minnibaeva, E., Phoung, T. T. T., Van, L. T., … Kazakova, O. (2022). Azepanodipterocarpol is potential candidate for inhibits influenza H1N1 type among other lupane, oleanane, and dammarane A-ring amino-triterpenoids. Journal of Antibiotics, 75(5), 258–267. https://doi.org/10.1038/s41429-022-00514-w

Azepanodipterocarpol is potential candidate for inhibits influenza H1N1 type among other lupane, oleanane, and dammarane A-ring amino-triterpenoids

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