Oral isotretinoin

Abstract

Oral isotretinoin is listed on the Australian Pharmaceutical Benefits Scheme for patients with severe cystic acne that has failed to respond adequately to other therapy. A single course of isotretinoin induces a long-term remission in over 80% of these patients. A minority, usually after a prolonged remission, benefit from a subsequent course. Pregnancy prevention is of paramount importance for women taking isotretinoin as it is highly teratogenic. Extra caution is also needed if the patient has diabetes, hyperlipidaemia or a mood disorder, drinks heavily or has a very physically active lifestyle.