Determination of atropine in injection with β-cyclodextrin modified ion sensitive field effect transistor sensor

Abstract

A new atropine drug-FET sensor, which was made of an ISFET (ion sensitive field effect transistor) and a drug sensitive membrane prepared by adding electric active matter to a β-cyclodextrin solution, was developed. The pH influence, selectivity, response curve, reproducibility, stability, response time and life of this sensor were investigated. A preliminary application of the sensor was discussed as well. The experimental results indicated that the sensor showed a Nernst response to atropine with a slope of 58.0 mV/decade over the concentration range of 5.0×10-3 - 1.0×10-6 mol/L and the pH range of 5.0-8.5. The sensor detection limit was 8.0×10-7 mol/L. The performance of this sensor was very stable when it was used to determine atropine concentration in a medicinal injection. The obtained results agreed well with the pharmacopoeia method. © 2005 by MDPI.