Genes associated with fibro-osseous lesion: A review article

Abstract

The Fibro osseous lesion is a group of diseases or lesions that are affecting the skeletal tissue which frequently includes maxilla and mandible. The disease can also be easily described as bone disorders. A lot of research and work has been done regarding this serious disease though due to similarities in its radiographical features or histopathology, it is been very complicating to diagnose and classify FOLs. The review article focuses on different diseases that come under the fibro-osseous lesion and the genes which have been associated with the respective one in an orderly manner with their Histopathological features. One to understand this lesion the clinical correlation with radiographic involvement is necessary to diagnose this kind of dysplasia. The article also throws light on that the mandible and maxilla also suffer from localized and generalized forms of skeletal dysplasia which results in disproportionate short stature. These dysplasias always remain in a confused manner for their nomenclature. Much classification has been proposed by the different authors in different years regarding the FOLs based on gene or protein defect in these disorders.