Layer-by-layer functionalized nanotube arrays: A versatile microfluidic platform for biodetection

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Abstract

We demonstrate the layer-by-layer (LbL) assembly of polyelectrolyte multilayers (PEM) on three-dimensional nanofiber scaffolds. High porosity (99%) aligned carbon nanotube (CNT) arrays are photolithographically patterned into elements that act as textured scaffolds for the creation of functionally coated (nano)porous materials. Nanometer-scale bilayers of poly(allylamine hydrochlor-ide)/poly(styrene sulfonate) (PAH/SPS) are formed conformally on the individual nanotubes by repeated deposition from aqueous solution in microfluidic channels. Computational and experimental results show that the LbL deposition is dominated by the diffusive transport of the polymeric constituents, and we use this understanding to demonstrate spatial tailoring on the patterned nanoporous elements. A proof-of-principle application, microfluidic bioparticle capture using N-hydroxysuccinimide-biotin binding for the isolation of prostate-specific antigen (PSA), is demonstrated.

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Yost, A. L., Shahsavari, S., Bradwell, G. M., Polak, R., Fachin, F., Cohen, R. E., … Wardle, B. L. (2015). Layer-by-layer functionalized nanotube arrays: A versatile microfluidic platform for biodetection. Microsystems and Nanoengineering, 1. https://doi.org/10.1038/micronano.2015.37

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