Maternal glucose administration for facilitating tests of fetal wellbeing

Abstract

BACKGROUND: Antenatal maternal glucose administration has been suggested to improve the efficiency of antepartum fetal heart rate testing. OBJECTIVES: The objective of this review was to assess the merits or adverse effects of antenatal maternal glucose administration in conjunction with tests of fetal wellbeing. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group trials register in June 2001. SELECTION CRITERIA: All published and unpublished randomized controlled trials assessing the merits of antenatal maternal (oral or intravenous) glucose administration in conjunction with tests of fetal wellbeing. DATA COLLECTION AND ANALYSIS: Both reviewers independently extracted data and assessed trial quality. Authors of published and unpublished trials were contacted for further information. MAIN RESULTS: A total of two trials with a total of 708 participants were included. Antenatal maternal glucose administration did not decrease the incidence of non-reactive antenatal cardiotocography tests. REVIEWER'S CONCLUSIONS: Antenatal maternal glucose administration has not been shown to reduce non-reactive cardiotocography. More trials are needed to further substantiate this and to determine not only the optimum dose, but also to evaluate the efficacy, predictive reliability, safety and perinatal outcome of glucose administration in conjunction with cardiotocography and also other tests of fetal wellbeing.