Peptide antibiotic k-582 production in relation to amino acid metabolism in metarrhizium anisopliae

Abstract

Formation of the basic antibiotic, K-582 was stimulated by supplying Metarrhizium anisopliae U-47 with several amino acids present in its structure. The addition of L-arginine to the basal medium resulted in the almost exclusive formation of K-582 B, while L-lysine increased K-582 A formation. Some carbon sources were observed to have effects similar to those obtained with the above mentioned amino acids. © 1984, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.