114P Comparison of conventional and hypo fractionation radiation schedule on pulmonary function test in carcinoma of the breast as an acute effect

Abstract

Background: To evaluate the acute effect of different fractionation schedule (hypofractionation and convention fraction) of radiation therapy on lung in patient of carcinoma breast. Methods: This randomised prospective multicentric study was conducted with a 130 breast cancer patients who are all candidate for the adjuvant radiation therapy. Spirometry based PFT were done before radiation therapy as base line, at 1 month after RT and once in every 3 months.out of 130 patients, 70 were treated with hypofractionation (40Gy in 15#) and other 60 were treated with conventional fractionation schedule (50Gy in 25#) to chest wall and SCF(+/-). All patients were treated with 3DCRT as per the departmental protocol of the institutes. The relative changes in the PFT parameters were correlated with irradiated lung dose by using dose volume histogram (DVH). Relevant statistical tests were used for analysis. Results: Conclusions: There will be more acute lung reaction (reflected on reduction on PT parameters) in conventional fractionation arm, patient with age more than 60 and ipsilateral lung volume of less than 950cc. Thus selection off patient still need to be caution on fractionation schedule. Further follow up to know weather the acute effect will reflect on late radiation effect.