FRI0509 The factors associated with anxiety/depressive disorders in behÇet's disease patients

Abstract

Background: The anxiety/depressive disorders (ADD) is a special psychopathological problem for Behcet's Disease (BD) patients. ADD has high rates in BD, but their causes aren't enough investigated. Objective(s): To determine the main factors associated with anxiety/depressive disorders in BD patients. Method(s): The investigation has been realised in accordance with the interdisciplinary program "Stress factors and mental disorders in immune-mediated inflammatory rheumatic diseases". 116 BD patients were enrolled in the study. The majority of patients were men (69,8%), natives of the North Caucasus (51,9%), with mean age (M+/-m) 33,3+/-0,98 years. All the patients met the criteria of the International Study Group for BD (1990) classification. The disease activity was assessed by scoring system BDCAF. ADD were diagnosed by psychiatrist in accordance with the ICD-10 in semi-structured interview. The severity of depression was evaluated by Montgomery- Asberg Depression Rating Scale (MADRS) and anxiety - by Hamilton Anxiety Rating Scale (HAM-A). The severity of stress was evaluated by PSS-10 scale. Result(s): ADD were diagnosed in 87 BD patients (75%). The dysthymia (29,3%) and recurrent depressive disorder (21,5%) prevailed in these patients, generalised anxiety disorder (6,03%) and single depressive episode (7,76%) were rare. Cognitive disorders of different severity were diagnosed in 87 (75%) patients. The presence of ADD didn't depend on gender and duration of the disease. The factors associated with ADD were found during Pearson correlations. Then linear regression analysis was done and obtaining prognostic model showed that ADD was associated with: sleep disorders (beta=0,401), asthenia (beta=0,176), cognitive disorders (beta=0,145), chronic stress (beta=0,036) and stress severity (PSS-10 score) (beta=0,115), age of eye damage (beta=0,135), onset of ADD before BD onset (beta=0,147), pure quality of life (QoL) estimated by visual analogue scale (VAS) (beta=0,163), gastrointestinal BD symptoms (beta=0,101), higher CRP level (beta=0,174), younger age of patients (beta=-0,053) and early childhood trauma (before 7 years old) (beta=0,15) (area under the ROC curve=0,957) (figure 1). Figure 1 Area under the ROC curve=0957 Conclusion(s): The results demonstrated high prevalence of ADD in surveyed BD patients. ADD in BD is much more associated with early childhood trauma, chronic severe stress, onset before BD, younger age of patients, older age of eye damage, gastrointestinal involvement, higher CRP level, accompanied by sleep disturbances, asthenia, cognitive disorders and had a negative impact on QoL. (Figure Presented).