The study of malondialdehyde, uric acid, and C-reactive protein in obese and healthy pregnant women in different trimesters

Abstract

Pregnancy or gestation is a complex period of human growth and development. It is a physiological process associated with the development of maternal pathologies, such as metabolic disorders (i.e. maternal obesity and hypercholesterolemia), preeclampsia and gestational diabetes mellitus. Obesity is a worldwide epidemic, it is considered a most common medical condition in women of reproductive age, during pregnancy has short term and long term adverse consequences for both mother and child, it is caused insulin resistance. There area closes relationship between the obesity, OS, antioxidants and inflammation. The aim of this study was the assessment to oxidative stress factor changes, uric acid and CRP in obese pregnant women in Misan province.The study included (60) obese pregnant women, aged (25 -35) years. The study conducted duringNovember2018to February 2019. Diagnosed parameters done using enzyme-linked immunosorbent assay (ELISA) and mind ray (BS -230). Our results reveledalmostparameters increased during pregnancy, highestincrease in the third trimesters, it is increased significantly (p ≤0.05) in comparison with the first and second trimesters. Results of current study showed clearly the following conclusion in obese pregnant women all parameters in our study elevatedduringtrimesters.