Palladium-Catalyzed One-Pot Carbonylative Sonogashira Reaction Employing Formic acid as the CO Source

Abstract

A convenient palladium-catalyzed carbonylative coupling of aryl iodides and terminal alkynes with formic acid as the CO precursor has been developed. A variety of alkynones were obtained in good yields in a one-pot manner for the first time. CO Confidential: A convenient palladium-catalyzed Sonogashira carbonylative coupling reaction for the synthesis of alkynones has been developed. Formic acid was used as the CO source, and the desired alkynones were isolated in moderate-to-good yields under mild reaction conditions. Notably, this is the first example of a one-pot carbonylative Sonogashira reaction with formic acid as the CO source.