Possible clinical applications of electron discharge at extremely low energy level for suppression of oxidative stress: Introduction of “e-vitamin” therapy

Abstract

Antioxidative treatment delivered using an electron discharge at extremely low energy, also known as “e-Vitamin” therapy, has been demonstrated in vitro by the exposure of a physiological saline solution to the electron discharge, which results in an increase of pH and negative value of oxidation and reduction potential indicating an increased electron density in the solution and the reduction of Fe3+ and glutathione disulphate. More importantly, a significant reduction of liver damage was observed on administration of the treated saline solution to rats in the hepatic ischemic reperfusion model. In addition, e-Vitamin therapy delivered using a direct current-type dielectric barrier discharge system significantly decreased both alanine aminotransferase levels (an indicator of liver inflammation) and hepatic malondialdehyde levels (an indicator of oxidative stress), as well as reducing blood glucose levels in rats with type 2 diabetes and hepatic steatosis. These results suggest that e-Vitamin therapy merits investigation as a clinical intervention in patients with type 2 diabetes and fatty liver disease.