One-pot synthesis of dihydrobenzo[4,5][1,3]oxazino[2,3-A] isoquinolines via a silver(I)-catalyzed cascade approach

Abstract

An efficient approach for the synthesis of biologically interesting fused tetracyclic isoquinolines in high yields and with a broad substrate scope has been developed. The strategy features an AgNO3 catalyzed 'one-pot' cascade process involving formation of two new C-N bonds and one new C-O bond. © 2013 by the authors.