Profilaksis isoniazid merupakan faktor protektif kejadian tuberkulosis pasien HIV/AIDS di klinik VCT RSUP Sanglah Denpasar

Abstract

Background: Human Immunodeficiency Virus (HIV) infection can increase susceptibility to Mycobacterium tuberculosis (TB) infection. Since Anti Retroviral Therapy (ART) alone is not enough to reduce the risk of TB in HIV patient, a special interventions are needed, namely Isoniazid Preventive Therapy (IPT). In Indonesia, this strategy has not been fully implemented. Therefore, it is necessary to do a research on protective role of IPT against the incidence of TB in HIV/AIDS patients. Objective: To determine the protective role of IPT in the incidence of TB in patients with HIV/AIDS at the Voluntary and Counseling Test (VCT) Clinic at Sanglah Hospital, Denpasar from 2014 to 2016. Methods: An observational analytic study with retrospective cohort design was done. All patients who were on HAART therapy and received IPT within the study period were included. The research population were HIV patients who were enrolled in ART follow-up care. Result: The study found a significant protection effects of IPT on TB incidence [RR: 2.05; 95% IK 1.78-2.37; p=0.02). There was no TB incidence at patients who have received IPT. Conclusion: Isoniazid Preventive Therapy (IPT) has a significant protection effect on TB incidence. Keywords: IPT, Risk of TB, HIV infection.