Abstract
A simple method has been developed for four-component synthesis of disubstituted 1,3,4-oxadiazoles using (N-isocyanimino)triphenylphosphorane, a primary amine, a carboxylic acid and biacetyl in CH2Cl2 by the Ugi- 4CR/aza-Wittig sequence at room temperature in excellent yields.
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Ramazani, A., Abdian, B., Nasrabadi, F. Z., Shajari, N., & Ranjdoost, Z. (2012). Four-Component preparation of disubstituted 1,3,4-Oxadiazoles from (N-isocyanimino)triphenylphosphorane, phenylacetylenecarboxylic acid, biacetyl and primary amines. Bulletin of the Korean Chemical Society, 33(11), 3701–3705. https://doi.org/10.5012/bkcs.2012.33.11.3701
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