Cardiotonic effects of Terminalia arjuna extracts on guinea pig heart in vitro

Abstract

we investigated the effects of fruit and bark extracts of terminalia arjuna on the rate and contraction of guinea pig heart in vitro. immediately after killing, the heart was connected to a perfusion apparatus containing oxygenated double-dextrose mcwins solution with fresh arjun fruit and bark experimental extracts. the apex of the heart was then connected to a recording drum through a metallic hook and the rate and height (force) of contractions were recorded on a smoked drum. the heights of contraction for fruit extract and bark extract were significantly higher than that for normal saline (p<0.001), while they were significantly lower than that for adrenaline (p<0.01). addition of verapamil caused a significant blockade in the heights of contraction produced by extracts of t arjuna (p<0.01), while heart rate was not affected. the cardiotonic effect of t arjuna was probably mediated through high concentration of ca ++ present in the plant.