Electroencephalography studies of hypoxic ischemia in fetal and neonatal animal models

Abstract

Alongside clinical achievements, experiments conducted on animal models (including primate or non-primate) have been effective in the understanding of various pathophysiological aspects of perinatal hypoxic/ischemic encephalopathy (HIE). Due to the reasonably fair degree of flexibility with experiments, most of the research around HIE in the literature has been largely concerned with the neurodevelopmental outcome or how the frequency and duration of HI seizures could relate to the severity of perinatal brain injury, following HI insult. This survey concentrates on how EEG experimental studies using asphyxiated animal models (in rodents, piglets, sheep and non-human primate monkeys) provide a unique opportunity to examine from the exact time of HI event to help gain insights into HIE where human studies become difficult. Abbasi Hamid 1 Department of Engineering Science, the University of Auckland, Auckland Unsworth Charles 2 Department of Engineering Science, the University of Auckland, Auckland Abbasi H, Bennet L, Gunn A, Unsworth C (2019a) Latent phase detection of hypoxic-ischemic spike transients in the EEG of preterm fetal sheep using reverse biorthogonal wavelets & fuzzy classifier.