The impact of epigenetic landscape on ovarian cells in infertile older women undergoing IVF procedures

Abstract

The constant decline in fertility and older reproductive age is the major cause of low clinical pregnancy rates in industrialised countries. Epigenetic mechanisms impact on proper embryonic development in women undergoing in vitro fertilisation (IVF) protocols. Here, we describe the main epigenetic modifications that may influence female reproduction and could affect IVF success. Graphical Abstract: [Figure not available: see fulltext.].