Acupuncture effects on emotional reactivity of youth with self-reported depressive symptoms

Abstract

Background: Emotional symptomatology is a hallmark of depression. Antidepressant often fail to effectively target emotional blunting, while acupuncture, by contrast, has emerged as a promising alternative. However, the exact electrophysiologic mechanisms remain unclear. This study aimed to investigate how acupuncture influences emotional reactivity in youth with self-reported depressive symptoms. Methods: A modified oddball paradigm incorporating a negative emotional valence deviant, combined with event-related potential analysis, was used to measure emotional reactivity before and after intervention. Seventy individuals exhibiting depressive symptoms in the previous 2 weeks, were randomly assigned to either a verum or sham acupuncture group. Electroencephalogram data from 59 participants were analyzed following preprocessing and quality assessment. Occipital P1, N170, frontal N1, N2, and parietal P3 components were extracted. The Positive and Negative Affect Schedule (PANAS) was completed after each oddball session. The Massachusetts General Hospital Acupuncture Sensation Scale (MASS) was completed after each intervention session. Results: The MASS Index was significantly higher in the verum group. However, significant increases in occipital P1, N170, frontal N1, N2, and parietal P3 amplitudes for high-negative, mild-negative, and neutral pictures were observed after the intervention in both the verum and sham groups, with no significant difference between the groups. Additionally, both groups induced PANAS changes, and positive effect changes were significantly correlated with N170 and P1 (in response to high-negative pictures) changes in the sham group. Conclusion: Acupuncture altered emotional reactivity in youth with depressive symptoms, highlighting its potential role, albeit possibly non-specific, in depression prevention and treatment.