Insulin resistance and secretion change after 3 years follow-up and the risk for developing diabetes in non-diabetic adults

Abstract

Purpose : To determine 3-years natural change of insulin resistance and secretion in non-diabetic Chinese adults and corresponding risk for developing diabetes. Methods : Population-based cohort study was performed in Chinese adults (35-74 years) from 2009 to 2015. Fasting plasma glucose and serum insulin was determined in 1882 subjects (701 men) at baseline and re-tested in 1087 (377 men). Insulin resistance was estimated with HOMA insulin resistance index (HOMA-IR) and insulin secretion with HOMA insulin secretion index (HOMA-IS). The change of HOMA-IR and HOMA-IS was calculated as: the value at follow-up minus that at baseline