Copper-catalyzed intermolecular oxyamination of olefins using carboxylic acids and O-benzoy I hydroxy lamines

Abstract

This paper reports a novel approach for the direct and facile synthesis of 1, 2-oxyamino moieties via an intermolecular copper-catalyzed oxyamination of olefins. This strategy utilizes O-benzoylhydroxylamines as an electrophilic amine source and carboxylic acids as a nucleophilic oxygen source to achieve a modular difunctionalization of olefins. The reaction proceeded in a regioselective manner with moderate to good yields, exhibiting a broad scope of carboxylic acid, amine, and olefin substrates.