Emerging Role of Dapsone in the Management of Acne Vulgaris: Review Article

Abstract

Background: Skin illness Acne Vulgaris (AV) is characterized by excessive sebum production, follicular hyperkeratinization, and long-term pilosebaceous unit irritation. Acne can persist into adulthood in 12-14% of instances, resulting in deformity and chronic scarring that can have psychological and social consequences. Acne scars, feelings of negative effects on psychology, isolation from society, and depression can all be long-term repercussions of the condition. In a small percentage of patients with nodulocystic acne, the anti-inflammatory drug Dapsone, developed in the 1950s, was found to be beneficial. However, the risk of systemic side effects has limited the use of dapsone in clinical practice. Topical dapsone gel was licensed for acne treatment following two double-blind, randomized trials that established its therapeutic efficacy. Objective: Summarize the role that Dapsone plays in the treatment of Acne Vulgaris. Methods: The databases were searched for articles published in English in 3 databases [PubMed – Google scholar-science direct] and Boolean operators (AND, OR, NOT) had been used such as [Management of Acne Vulgaris AND Dapsone OR Acne Vulgaris] and in peer-reviewed articles between March 2001 and April 2020. Conclusion: Acne vulgaris can be effectively treated with topical Dapsone, according to clinical trials.