Studies on the Metabolic Products of a Strain of Aspergillus fumigatus (DH 413)1). IV. Biosynthesis of Toluquinones and Chemical Structures of New Metabolites

Abstract

Four new compounds, spinulosin—hydrate (VI), spinulosin quinol-hydrate (II), dihydrospinulosinquinol (VII), and fumigatin chlorohydrin (VIII) were isolated from the culture medium of Aspergillus fumigatus DH 413 and Fersenius 4399 by ion exchange chromatography, and their chemical structures were determined. From the tracer experiments using 14C-labeled compounds, the metabolic relationships among metabolites were proposed as shown in Chart 4. The key different point between spinulosin producing and unproducing strains in Aspergillus fumigatus were also discussed. © 1970, The Pharmaceutical Society of Japan. All rights reserved.