A Multimodal Auxiliary Classification System for Osteosarcoma Histopathological Images Based on Deep Active Learning

Abstract

Histopathological examination is an important criterion in the clinical diagnosis of osteosarcoma. With the improvement of hardware technology and computing power, pathological image analysis systems based on artificial intelligence have been widely used. However, classifying numerous intricate pathology images by hand is a tiresome task for pathologists. The lack of labeling data makes the system costly and difficult to build. This study constructs a classification assistance system (OHIcsA) based on active learning (AL) and a generative adversarial network (GAN). The system initially uses a small, labeled training set to train the classifier. Then, the most informative samples from the unlabeled images are selected for expert annotation. To retrain the network, the final chosen images are added to the initial labeled dataset. Experiments on real datasets show that our proposed method achieves high classification performance with an AUC value of 0.995 and an accuracy value of 0.989 using a small amount of labeled data. It reduces the cost of building a medical system. Clinical diagnosis can be aided by the system’s findings, which can also increase the effectiveness and verifiable accuracy of doctors.