Intra-arterial nitroprusside treatment of acute experimental vasospasm

Abstract

The effect of infra-arterial sodium nitroprusside infusions on acute experimental basilar artery spasm was studied in dogs. Vasospasm produced by subarachnoid hemorrhage at normal intracranial pressure was partially relieved by nitroprusside. When giren by the infra-arterial route, 15 times the recommended maximum intravenous dose can be infused without significant hypotension or elevation in intracranial pressure. © 1980 American Heart Association, Inc.