Repeatability and reciprocity of the cone optoretinogram

Abstract

Optoretinography has enabled noninvasive visualization of physiological changes in cone photoreceptors exposed to light. Understanding the cone optoretinogram in healthy subjects is essential for establishing it as a biomarker for cone function in disease. Here, we measure the population cone intensity optoretinogram in healthy adults, for multiple irradiance/duration combinations of visible stimuli with equal energy. We study the within and between session repeatability and reciprocity of the ORG in five healthy subjects. We find the cone optoretinogram exhibits equivalent amplitudes for equal-energy stimuli. We also find good within-subject repeatability, which allows us to show differences across the five subjects.