Structure of the human 20S U5 snRNP

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Abstract

The 20S U5 small nuclear ribonucleoprotein particle (snRNP) is a 17-subunit RNA–protein complex and a precursor of the U4/U6.U5 tri-snRNP, the major building block of the precatalytic spliceosome. CD2BP2 is a hallmark protein of the 20S U5 snRNP, absent from the mature tri-snRNP. Here we report a high-resolution cryogenic electron microscopy structure of the 20S U5 snRNP, shedding light on the mutually exclusive interfaces utilized during tri-snRNP assembly and the role of the CD2BP2 in facilitating this process.

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Schneider, S., Brandina, I., Peter, D., Lagad, S., Fraudeau, A., Portell-Montserrat, J., … Galej, W. P. (2024). Structure of the human 20S U5 snRNP. Nature Structural and Molecular Biology, 31(5), 752–756. https://doi.org/10.1038/s41594-024-01250-5

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