Effects of welding fume particles on heamatological parameters in male Albino rats

Abstract

Background and objective: Exposure evidence to welding fume aerosols demonstrates that particulate air pollutants can cause both pulmonary and airway inflammation. How-ever, few data show that particulates pollutants can induce systemic inflammatory re-sponses in animals. The aim of this study was to test whether exposure to welding fume by inhalation of its fine and ultra fine particles and different compositions of the electrical weld-ing processes would produce physiological disorders for the blood parameters of exposed rat’s animal. Methods: We conducted the study using hematology coulter counter to analyze whole blood samples of rats after exposure to welding fumes. We investigated the effect of wield-ing fume exposure on some hematological parameters such as the red blood corpuscles (RBCs), white blood cells (WBCs) and platelet parameters. Fourteen male albino rats were randomly assigned to control or wielding fume inhalation. Results: Significant decrease were observed after four weeks of wielding fume inhalation in the hemoglobin (Hb) concentration, RBCs count, hemoglobin (Hb), packed cell vol-ume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), red distribution width (RDW), mean corpuscular hemoglobin concentration (MCHC), Platelete counts (PLTs) and platelete large cell ratio ( P-LCR ).On the other hand, platelet distribu-tion width (PDW). Conclusion: We conclude that inhalation of wielding fume for a long time influence the progression of anemia and inflammation suggesting that welding fume profoundly affects whole-blood profiles.