Drink containing adzuki polyphenol inhibits weight gain in female mice on high-fat diets

Abstract

Hepatic disorders were absent in female mice given both a high-fat diet and a drink containing adzuki polyphenol. (APP) for seven weeks, with no significant difference observed in the amount of feces between the experimental and control (high-fat diet only) mice. However, the average weight of mice given the APP drink was significantly lower than that of control mice, and the difference in the weight of ovary circumference fat was particularly marked. Additionally, the fat content of the feces of the mice given the APP drink was significantly higher than that of control mice, indicating greater fat elimination via the feces. An in vivo experiment found an inhibitory effect on pancreatic-lipase-activity dependent on an APP concentration with an IC 50 of 38.0 ppm. Based on these results, it was suggested that in female mice given both a high-fat diet and the APP drink for a long period of time, APP inhibits pancreatic lipase activity, thus blocking the digestion and absorption of dietary fat and promoting fat elimination in the feces, thereby controlling weight gain.