Upaya Peningkatan Sifat Farmasetika Eksipien Sediaan Tablet dari Pati Ubi Jalar

Abstract

Indonesia is one of the biggest producer of sweet potato starch in the world, but still import 100% modified starch from other country. Sweet potato has a potential utility as a raw material of tablet excipient, but still needs physical and chemical modifications to produce derivatives that have better pharmaceutical characteristic. Therefore, this research aimed to develop tablet dosage form from sweet potato starch (Ipomoea batatas Lamk.) that was modified using physicochemical process in order to improve the pharmaceutical characteristic and compared it with native starch. The excipient was made of three kind of modification methods. The method was modified with direct heating/steaming, modified with penthanol-1, and modified with acetylation of acetate acid process. Based on descriptive- comparative analysis method, it can show that sweet potato starch modified with penthanol- 1 had a higher hardness value (??̅=2.55±0.34) compared with native starch (??̅ =1.00±0.08). Particle size distribution of modified starch with acetate acid (??̅=15.20±1.79) was greater than the other modified starch. Native starch had a good flow properties (CI=18,9%±1,52) compared with modified starch. From this analysis result, it can be concluded that modified starch characteristic was better than native starch. Key