Effect of Zearalenone Administrated at Late Gestation Days on Fertility of The F-1 Offspring in Swiss webster (Mus musculus)

Abstract

Zearalenone solution was given to dams mice subcutaneously at a dose of 30 mg/kg body weight at the age of pregnancy 13 to 18 days. Control mice were given only sesame oil. Furthermore, dams mice were allowed to deliver their litter and pups were weaned on 21 days of age. The live birth index and viability of the F-1 offspring were recorded. Determination of fertility of the F-1 offspring were undertaken by mating interlitters. On days 18 of gestation, the F-1 offspring were killed by cervical dislocation. The observation was performed on the number of live or dead fetus, embryo resorption, the number of implantation and the percentage of gestation loss. The result revealed that administration of zearalenone on days 13 to 18 of gestation caused a significant decreasein the number of implantation as the result of mating between control male with treated female and treated male with tretaed female of the F-1 offspring. It could be concluded that in the F-1 offspring, zearalenone interfered the process of ovarian develoment, stimulated the differentation of the uterus, decreased the fertility of the female and the effect of zearalenon was more persistent in the female than in the male.