Skip to main content
Journal ArticleOPEN ACCESS

Efficient microwave assisted syntheses of 2,5-diketopiperazines in aqueous media

Molecules (2009) 14(8) 2836-2849
DOI: 10.3390/molecules14082836
47Citations
Citations of this article
68Readers
Mendeley users who have this article in their library.

Abstract

Aqueous in situ one-pot N-Boc-deprotection-cyclization of Nα-Boc-dipeptidyltert-butyl and methyl esters under microwave irradiation afforded 2,5-diketopiperazines (DKPs) in excellent yields. This protocol is rapid, safe, environmentally friendly, and highly efficient, and showed that the tert-butoxy moiety is also an excellent leaving group for these cyclizations. © 2009.

Author supplied keywords

References Powered by Scopus

Synthetic Studies of Biologically Active Marine Cyclopeptides

Chemical Reviews
649Citations
N/AReaders
Get full text

Practical Microwave Synthesis for Organic Chemists: Strategies, Instruments, and Protocols

Practical Microwave Synthesis for Organic Chemists: Strategies, Instruments, and Protocols
516Citations
N/AReaders
Get full text

Controlled microwave heating in modern organic synthesis: Highlights from the 2004-2008 literature

Molecular Diversity
468Citations
N/AReaders
Get full text
View more at Scopus

Cited by Powered by Scopus

Synthesis of peptides and pyrazines from β-amino alcohols through extrusion of h <inf>2</inf> catalyzed by ruthenium pincer complexes: Ligand-controlled selectivity

Angewandte Chemie - International Edition
145Citations
N/AReaders
Get full text

Microwave-assisted organic synthesis: General considerations and transformations of heterocyclic compounds

Current Organic Chemistry
91Citations
N/AReaders
Get full text

Self-Assembled Peptide Nano-Superstructure towards Enzyme Mimicking Hydrolysis

Angewandte Chemie - International Edition
85Citations
N/AReaders
Get full text
View more at Scopus

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Pérez-Picaso, L., Escalante, J., Olivo, H. F., & Rios, M. Y. (2009). Efficient microwave assisted syntheses of 2,5-diketopiperazines in aqueous media. Molecules, 14(8), 2836–2849. https://doi.org/10.3390/molecules14082836

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 37

74%

Researcher 7

14%

Professor / Associate Prof. 4

8%

Lecturer / Post doc 2

4%

Readers' Discipline

Tooltip

Chemistry 47

90%

Agricultural and Biological Sciences 2

4%

Biochemistry, Genetics and Molecular Bi... 2

4%

Chemical Engineering 1

2%

Save time finding and organizing research with Mendeley

Sign up for free