Immunology study for NDV treatment in mice Bearing mammary adenocarcinoma tumor

Abstract

Newcastle disease virus selectively kills human cancer cells versus normal cells.Newcastle disease virus has pleiotropic immune stimulatory properties. This study was conducted to investigate the ability of Iraqi strain of NDV to induce immune stimulation when used as oncolytic agent by intratumoral injection, IL-2 and IFN-gamm as well as CD8 and CD56 were used as parameters to determine of immune stimulation properties. The results showed high immune stimulatory effect for Iraqi strain of NDV.