Dissecting complement blockade for clinic use

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Abstract

In this issue of Blood, Peffault de Latour et al describe ex vivo measurements of complement activity in paroxysmal nocturnal hemoglobinuria (PNH) patients on eculizumab treatment. This is the first systematic pharmacodynamic (PD) study of eculizumab in PNH patients which shows that CH50 is a promising biomarker of therapeutic complement blockade.

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Risitano, A. M. (2015, January 29). Dissecting complement blockade for clinic use. Blood. American Society of Hematology. https://doi.org/10.1182/blood-2014-12-616300

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