Synthesis and study antimicrobial activities of some novel tetrazole derivatives

Abstract

F OUR (2-phenol derivatives) were coupled with 1H-tetrazole-5-diazonium chloride to synthesize four new compounds namely 4-((1H-tetrazol-5-yl)diazenyl)-2-alkylylphenol (Ta-d). These prepared Azophenols reacted with two 4-alkoxy acids (8 and 10) to form two new series of 4-((1H-tetrazol-5-yl) diazenyl)-2-(alkyl)-phenyl-4-(octyloxy) benzoates T8a-d and 4-((1H-tetrazol-5-yl)diazenyl)-2-(alkyl)-phenyl-4-(decyloxy) benzoates T10a-d respectively. The structures of the twelve synthesized compounds were confirmed using the conventional tools of analysis, Elemental Analysis, FT-IR and 1H-NMR spectroscopy. The biological activity of the prepared compounds as anti-fungi and anti-bacteria was studied. Most of the prepared compounds possessed good antimicrobial action for Gram-positive and Gram-negative bacteria, whereas they gave no action on Aspergillus fumigatus or Candida albicans.