Modelling cerebrovascular reactivity: A novel near-infrared biomarker of cerebral autoregulation?

Abstract

Understanding changes in cerebral oxygenation, haemodynamics and metabolism holds the key to individualised, optimised therapy after acute brain injury. Near-infrared spectroscopy (NIRS) offers the potential for non-invasive, continuous bedside measurement of surrogates for these processes. Interest has grown in applying this technique to interpret cerebrovascular pressure reactivity (CVPR), a surrogate of the brain's ability to autoregulate blood flow. We describe a physiological model-based approach to NIRS interpretation which predicts autoregulatory efficiency from a model parameter k-aut. Data from three critically brain-injured patients exhibiting a change in CVPR were investigated. An optimal value for k-aut was determined to minimise the difference between measured and simulated outputs. Optimal values for k-aut appropriately tracked changes in CVPR under most circumstances. Further development of this technique could be used to track CVPR providing targets for individualised management of patients with altered vascular reactivity, minimising secondary neurological insults. © 2013 Springer Science+Business Media New York.