Correlation between Serum Inflammatory and Oxidative Stress Markers with Blood Pressure in Preeclampsia

Abstract

Objectives: To evaluate the serum pro-inflammatory cytokines (Tumor necrosis alpha (TNF α)), oxidative stress marker(Malondialdehyde(MDA)) and serum antioxidant biomarker (Superoxide dismutase(SOD)) and study their correlations with blood pressure (BP) in preeclampsia (PE). Methods: Fifty pregnant women (18-35 years old) were divided into two groups each with 25 pregnant women: preeclampsia group and control group. Results: Blood pressure, mean serum TNF α, and MDAwere significantly higher, while, the mean serum value of SOD was significantly lower in the pregnant women with preeclampsia than in the control pregnant women. Also, there was a significant positive correlation between TNF α, MDA and BP. Conclusion: Elevated both serum TNF α, and MDA and decreased in SOD are the possible mechanisms involved in the pathogenesis of PE. Early detection of PE allow for planning of appropriate monitoring of PE and for prevention of complications.