Metal ion coordination interactions for biomolecule recognition: a review

Abstract

Molecular imprinting is an effective method to create selective binding sites in polymeric matrices for biomolecule recognition. This review gives recent improvements of the design and preparation of selective binding sites via metal coordination interactions in molecularly imprinted polymers (MIPs) and focuses on particularly metal coordination bonds between biomolecules such as amino acids, peptides, proteins and templated polymers. The discussion will evaluate key parameters for molecular imprinting in the perspective of metal coordination.