Chemical approaches to the re-structuring of proteins

Abstract

Methodologies for protein re-structuring have been developed enabling site specific side chain modification to either coded or non-coded residues. Procedures for the modification of the protein profile by attachment of either pendants or structural motifs have been delineated. Selectivity has been demonstrated on the basis of modulation of the -CH2- spacer, which interposes the functional group and the peptide backbone. © 1990 IUPAC