Letrozole induced linear lichenoid eruption in a patient with breast cancer: Case report

Abstract

Letrozole which acts as an aromatase inhibitor is used in the treatment strategy for oestrogen receptor-positive breast cancer. Cutaneous adverse effects including vasculitis and erythema nodosum of letrozole have been rarely described in literature. Recently reported eczematous skin eruption due to letrozole is one of the side effects that known to be developed by this drug. To our knowledge letrozole induced linear drug eruption has not been described in previous reports. We report 52-year-old woman who had unilateral pruritic lichenoid eruption over left tight following Blaschko lines after using letrozole. Cutaneous side effects of aromatase inhibitors can be serious as progressive cutaneous vasculitis or can be presented with mild cutaneous side effects as in our case. The physicians should be aware of this benign clinical condition. The decision to discontinue medication is dependent to the knowledge of severity of the side effects.