High-intensity arm resistance training does not lead to better outcomes than low-intensity resistance training in patients after subacute stroke: A randomized controlled trial

Abstract

Objective: To describe the effects of 2 levels of intensity of arm resistance training on grip strength, arm function, activities, participation, and adverse events in patients with subacute stroke. Design: A randomized controlled and preregistered trial with concealed allocation, assessor blinding and intention-to-treat analysis. Patients: Patients with subacute stroke and upper extremity hemiparesis. Methods: After randomization the experimental group received a 3-week high-intensity arm resistance training (HIT). The control group completed a 3-week low-intensity arm resistance training (LIT). The primary outcome was grip strength. Secondary outcomes included the Motricity Index, Fugl-Meyer Assessment for the upper limb, Box and Block Test, Goal Attainment Scale, Modified Ashworth Scale, and adverse events. All outcomes were assessed at baseline and after 3 weeks of intervention. Results: A total of 43 patients were investigated (HIT, n=23; LIT, n=20). All primary and secondary outcomes improved after the 3-week training, but no significant between-group differences were found. Adverse events occurred in 5% of training sessions (19/369). Conclusion: The results of this study did not show differential effects on any outcome of 2 forms of arm resistance training in patients with subacute stroke.